Motif ID: ELK1,4_GABP{A,B1}.p3

Z-value: 4.609


Transcription factors associated with ELK1,4_GABP{A,B1}.p3:

Gene SymbolEntrez IDGene Name
ELK1 2002 ELK1, member of ETS oncogene family
ELK4 2005 ELK4, ETS-domain protein (SRF accessory protein 1)
GABPA 2551 GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 2553 GA binding protein transcription factor, beta subunit 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GABPAhg19_v1_chr21_+_27107731_27107801-0.617.6e-09Click!
GABPB1hg19_v1_chr15_-_50647385_506474000.472.1e-05Click!
ELK1hg19_v1_chrX_-_47509864_475099910.309.7e-03Click!
ELK4hg19_v1_chr1_-_205600779_2056010330.181.1e-01Click!


Activity profile for motif ELK1,4_GABP{A,B1}.p3.

activity profile for motif ELK1,4_GABP{A,B1}.p3


Sorted Z-values histogram for motif ELK1,4_GABP{A,B1}.p3

Sorted Z-values for motif ELK1,4_GABP{A,B1}.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of ELK1,4_GABP{A,B1}.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_130964633 29.946 LOC286467
family with sequence similarity 195, member A pseudogene
chr19_+_6772705 20.790 NM_005428
VAV1
vav 1 guanine nucleotide exchange factor
chr3_-_196065191 19.280 TM4SF19
transmembrane 4 L six family member 19
chr21_-_15918635 18.587 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr1_-_222763081 17.851 NM_001201536
NM_005681
NM_139352
TAF1A


TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa


chr1_-_1310522 17.804 AURKAIP1
aurora kinase A interacting protein 1
chr21_+_46359966 17.638


chr9_-_37785013 17.244 EXOSC3
exosome component 3
chr9_-_37785064 17.160 NM_016042
NM_001002269
EXOSC3

exosome component 3

chr19_-_56092184 17.003 NM_152600
ZNF579
zinc finger protein 579
chr19_-_17516383 16.751 NM_004335
BST2
bone marrow stromal cell antigen 2
chr8_+_144373534 16.174 NM_030895
ZNF696
zinc finger protein 696
chr19_+_1776117 16.067


chr19_-_56632644 15.968 NM_001002836
ZNF787
zinc finger protein 787
chr9_-_37785052 15.818 EXOSC3
exosome component 3
chr3_-_196065243 15.781 NM_001204897
NM_001204898
NM_138461
TM4SF19


transmembrane 4 L six family member 19


chr2_+_169659099 15.770 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr19_+_6772801 15.569


chr15_+_101420004 15.354 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr2_+_234160374 15.249 ATG16L1
ATG16 autophagy related 16-like 1 (S. cerevisiae)
chr2_+_109745996 15.204 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr17_-_7165788 15.157 CLDN7
claudin 7
chr15_+_101420032 14.985 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr11_-_116658701 14.940 ZNF259
zinc finger protein 259
chr19_+_42387249 14.580 NM_004706
NM_198977
ARHGEF1

Rho guanine nucleotide exchange factor (GEF) 1

chr19_-_59031167 14.566 ZBTB45
zinc finger and BTB domain containing 45
chr2_+_201676659 14.524 BZW1
basic leucine zipper and W2 domains 1
chr4_+_84457390 14.457 NM_032717
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr4_-_39033981 14.445 NM_024943
TMEM156
transmembrane protein 156
chr1_-_153029987 14.432 NM_005988
SPRR2A
small proline-rich protein 2A
chr11_-_116658738 14.103 NM_003904
ZNF259
zinc finger protein 259
chr4_+_75230856 14.007 NM_001432
EREG
epiregulin
chr19_+_17862285 13.968 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr2_+_234160345 13.818 ATG16L1
ATG16 autophagy related 16-like 1 (S. cerevisiae)
chr2_+_234160317 13.602 ATG16L1
ATG16 autophagy related 16-like 1 (S. cerevisiae)
chr2_+_201676597 13.471 BZW1
basic leucine zipper and W2 domains 1
chr4_+_41937105 13.428 NM_018126
TMEM33
transmembrane protein 33
chr19_-_50370799 13.321 NM_007254
PNKP
polynucleotide kinase 3'-phosphatase
chr21_+_46359896 13.032 NM_058190
FAM207A
family with sequence similarity 207, member A
chr2_+_201676644 12.966 BZW1
basic leucine zipper and W2 domains 1
chr19_+_56186610 12.859 EPN1
epsin 1
chr19_+_56186426 12.816 NM_001130072
NM_013333
EPN1

epsin 1

chr21_-_33984865 12.791 NM_021254
C21orf59
chromosome 21 open reading frame 59
chr1_-_156698188 12.619 ISG20L2
interferon stimulated exonuclease gene 20kDa-like 2
chr5_-_126409171 12.541 NM_001164478
NM_001164479
C5orf63

chromosome 5 open reading frame 63

chr19_+_42387307 12.499 ARHGEF1
Rho guanine nucleotide exchange factor (GEF) 1
chr2_+_234160216 12.413 NM_001190266
NM_001190267
NM_017974
NM_030803
NM_198890
ATG16L1




ATG16 autophagy related 16-like 1 (S. cerevisiae)




chr11_+_44785975 12.410 NM_130783
TSPAN18
tetraspanin 18
chr19_+_58816757 12.347 ERVK3-1
endogenous retrovirus group K3, member 1
chr19_+_55897302 12.263 RPL28
ribosomal protein L28
chr9_-_136282963 12.229 REXO4
REX4, RNA exonuclease 4 homolog (S. cerevisiae)
chr3_+_44690216 12.153 NM_003420
ZNF35
zinc finger protein 35
chr4_+_84457256 12.059 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr12_+_133287382 12.009 NM_001170543
NM_001170544
NM_138575
PGAM5


phosphoglycerate mutase family member 5


chr22_-_50968475 11.928 NM_001113755
NM_001953
TYMP

thymidine phosphorylase

chr6_+_151561653 11.919 AKAP12
A kinase (PRKA) anchor protein 12
chr10_+_71390002 11.875 NM_145306
C10orf35
chromosome 10 open reading frame 35
chr22_+_46731598 11.842 TRMU
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
chr11_+_6502607 11.840 NM_012192
FXC1
fracture callus 1 homolog (rat)
chr1_-_36851484 11.839 NM_032017
STK40
serine/threonine kinase 40
chr12_-_49318663 11.832 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr16_+_2732526 11.777 KCTD5
potassium channel tetramerisation domain containing 5
chr19_+_44507076 11.721 NM_006300
ZNF230
zinc finger protein 230
chr3_+_57541973 11.711 NM_177966
PDE12
phosphodiesterase 12
chr19_+_44645728 11.686 ZNF234
zinc finger protein 234
chr19_+_38810461 11.681 NM_004823
KCNK6
potassium channel, subfamily K, member 6
chr16_+_2732475 11.679 NM_018992
KCTD5
potassium channel tetramerisation domain containing 5
chrX_-_153775774 11.634 NM_001042351
G6PD
glucose-6-phosphate dehydrogenase
chr16_+_69373414 11.613 NM_001199434
NM_016101
NIP7

nuclear import 7 homolog (S. cerevisiae)

chr9_-_37784785 11.588 EXOSC3
exosome component 3
chr16_+_2880172 11.584 NM_145252
ZG16B
zymogen granule protein 16 homolog B (rat)
chr20_-_5931036 11.579 NM_015939
TRMT6
tRNA methyltransferase 6 homolog (S. cerevisiae)
chr10_+_105156415 11.549 PDCD11
programmed cell death 11
chr15_-_65067696 11.545 NM_194272
RBPMS2
RNA binding protein with multiple splicing 2
chr3_-_194392913 11.543 LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chr17_-_8027396 11.538 NM_001165967
NM_032580
HES7

hairy and enhancer of split 7 (Drosophila)

chr6_+_111303240 11.458 NM_032194
RPF2
ribosome production factor 2 homolog (S. cerevisiae)
chr19_+_56166418 11.455 U2AF2
U2 small nuclear RNA auxiliary factor 2
chr10_+_105156382 11.447 NM_014976
PDCD11
programmed cell death 11
chr19_-_50083791 11.446 NM_015953
NOSIP
nitric oxide synthase interacting protein
chr9_+_127631500 11.437 ARPC5L
actin related protein 2/3 complex, subunit 5-like
chr3_-_170626425 11.423 NM_020390
EIF5A2
eukaryotic translation initiation factor 5A2
chr19_+_55897298 11.370 NM_000991
NM_001136134
NM_001136135
NM_001136136
NM_001136137
RPL28




ribosomal protein L28




chr3_-_194393205 11.368 NM_018385
LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chr2_-_188419049 11.348 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr19_+_47852537 11.306 NM_014681
DHX34
DEAH (Asp-Glu-Ala-His) box polypeptide 34
chr16_+_2653350 11.291 LOC652276
potassium channel tetramerisation domain containing 5 pseudogene
chr8_+_145582267 11.280 NM_024531
GPR172A
G protein-coupled receptor 172A
chr3_-_194392881 11.264 LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chr19_-_50083813 11.244 NOSIP
nitric oxide synthase interacting protein
chr7_-_107880492 11.242 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr10_+_105156430 11.223 PDCD11
programmed cell death 11
chr19_-_55791446 11.159 HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr4_+_110736636 11.068 NM_018983
NM_032993
GAR1

GAR1 ribonucleoprotein homolog (yeast)

chr3_-_194392938 11.064 LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chr4_+_41937368 10.888 TMEM33
transmembrane protein 33
chr4_+_8200918 10.830 NM_018986
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr2_-_188419185 10.824 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr19_-_55791727 10.814 NM_001130106
NM_012267
HSPBP1

HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1

chr19_+_44556163 10.788 NM_013361
ZNF223
zinc finger protein 223
chr2_-_31030271 10.768 NM_144575
CAPN13
calpain 13
chr5_+_34656482 10.713 RAI14
retinoic acid induced 14
chr7_-_5553305 10.694 NM_024963
FBXL18
F-box and leucine-rich repeat protein 18
chr4_+_30721865 10.655 NM_032456
NM_001173523
NM_002589
NM_032457
PCDH7



protocadherin 7



chr1_-_31230673 10.634 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr22_+_46731297 10.608 NM_018006
TRMU
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
chr3_+_15469052 10.585 NM_033083
EAF1
ELL associated factor 1
chr8_-_104427319 10.523 SLC25A32
solute carrier family 25, member 32
chr19_-_55791490 10.493 HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr9_-_136283291 10.482 REXO4
REX4, RNA exonuclease 4 homolog (S. cerevisiae)
chr3_-_50378238 10.453 NM_001206957
NM_007182
NM_170714
RASSF1


Ras association (RalGDS/AF-6) domain family member 1


chrX_-_153775427 10.399 G6PD
glucose-6-phosphate dehydrogenase
chr13_-_46756291 10.353 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr8_-_104427373 10.347 NM_030780
SLC25A32
solute carrier family 25, member 32
chr9_+_127631388 10.333 ARPC5L
actin related protein 2/3 complex, subunit 5-like
chr15_+_44092618 10.320 NM_001199885
NM_016400
C15orf63

chromosome 15 open reading frame 63

chr1_+_27648746 10.316 LOC644961
TMEM222
actin, beta pseudogene
transmembrane protein 222
chr13_-_46756295 10.315 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr9_-_136283157 10.230 NM_020385
REXO4
REX4, RNA exonuclease 4 homolog (S. cerevisiae)
chr1_+_118472364 10.176 NM_006784
WDR3
WD repeat domain 3
chr14_-_61190458 10.166 NM_017420
SIX4
SIX homeobox 4
chr7_-_2281797 10.159 FTSJ2
FtsJ homolog 2 (E. coli)
chr1_-_153044083 10.135 NM_001017418
SPRR2B
small proline-rich protein 2B
chr6_+_151561094 10.118 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr19_-_59069747 10.108 UBE2M
ubiquitin-conjugating enzyme E2M
chrX_+_129040076 10.097 NM_001166221
NM_006649
UTP14A

UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)

chr7_+_108210308 10.084 DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr19_-_44439410 10.081 NM_003425
ZNF45
zinc finger protein 45
chr8_+_22437983 10.068 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr1_-_52499432 10.010 NM_138417
KTI12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr15_-_34635306 9.999 NM_018648
NOP10
NOP10 ribonucleoprotein homolog (yeast)
chr2_+_231577624 9.995 CAB39
calcium binding protein 39
chr20_+_58630965 9.981 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr8_-_104427268 9.969 SLC25A32
solute carrier family 25, member 32
chr14_-_54955664 9.969 GMFB
glia maturation factor, beta
chr2_-_239148626 9.946 NM_001142853
NM_018645
HES6

hairy and enhancer of split 6 (Drosophila)

chr2_+_231577536 9.942 NM_016289
CAB39
calcium binding protein 39
chr21_-_33984657 9.906 C21orf59
chromosome 21 open reading frame 59
chr1_-_36851517 9.891 STK40
serine/threonine kinase 40
chr10_-_1102643 9.861 IDI1
isopentenyl-diphosphate delta isomerase 1
chr7_-_5553401 9.860 FBXL18
F-box and leucine-rich repeat protein 18
chr2_-_239148545 9.828 HES6
hairy and enhancer of split 6 (Drosophila)
chr6_-_7389941 9.808 NM_001170692
NM_001170693
NM_205864
CAGE1


cancer antigen 1


chr3_-_149470254 9.805 NM_016094
COMMD2
COMM domain containing 2
chr4_-_159644439 9.787 NM_005038
PPID
peptidylprolyl isomerase D
chr11_-_65769577 9.784 NM_001242481
NM_001242482
NM_001242483
NM_001242484
NM_001242485
NM_001242486
NM_032325
EIF1AD






eukaryotic translation initiation factor 1A domain containing






chr19_-_54663434 9.743 NM_024316
LENG1
leukocyte receptor cluster (LRC) member 1
chr12_-_58159386 9.738 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr17_+_48348766 9.729 NM_001168215
TMEM92
transmembrane protein 92
chr9_+_127631476 9.709 NM_030978
ARPC5L
actin related protein 2/3 complex, subunit 5-like
chr1_-_156786500 9.667 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr19_+_56186580 9.657 EPN1
epsin 1
chr1_+_234509213 9.656 NM_001206641
NM_001012985
C1orf31

chromosome 1 open reading frame 31

chr19_-_55791428 9.598 HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr11_-_64885124 9.593 NM_014205
ZNHIT2
zinc finger, HIT-type containing 2
chr1_+_183441612 9.557 SMG7
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr3_+_183967414 9.542 NM_014693
NM_032331
ECE2

endothelin converting enzyme 2

chr3_-_170626381 9.534 EIF5A2
eukaryotic translation initiation factor 5A2
chr13_-_46756326 9.486 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_118472346 9.486 WDR3
WD repeat domain 3
chr19_+_56186569 9.471 EPN1
epsin 1
chr6_+_126070895 9.390 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr5_+_34656367 9.360 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr19_+_40477032 9.333 NM_006503
NM_153001
PSMC4

proteasome (prosome, macropain) 26S subunit, ATPase, 4

chr17_+_79633724 9.278 NM_199287
CCDC137
coiled-coil domain containing 137
chr5_+_34656595 9.252 NM_001145520
RAI14
retinoic acid induced 14
chr3_-_149470230 9.229 COMMD2
COMM domain containing 2
chr10_-_99160987 9.203 RRP12
ribosomal RNA processing 12 homolog (S. cerevisiae)
chr5_-_137878890 9.194 ETF1
eukaryotic translation termination factor 1
chr10_-_99161013 9.189 NM_001145114
NM_015179
RRP12

ribosomal RNA processing 12 homolog (S. cerevisiae)

chr2_-_219536692 9.178 NM_022453
RNF25
ring finger protein 25
chr22_-_39928651 9.167 RPS19BP1
ribosomal protein S19 binding protein 1
chr12_-_93835986 9.132 NM_003348
UBE2N
ubiquitin-conjugating enzyme E2N
chr1_+_24117645 9.097 NM_007260
LYPLA2
lysophospholipase II
chr16_-_12009775 9.082 GSPT1
G1 to S phase transition 1
chr19_+_44645708 9.022 NM_001144824
NM_006630
ZNF234

zinc finger protein 234

chr1_-_109618568 9.007 NM_005645
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr12_-_93835723 8.994 UBE2N
ubiquitin-conjugating enzyme E2N
chr4_+_110736911 8.961 GAR1
GAR1 ribonucleoprotein homolog (yeast)
chr8_+_33342684 8.947 NM_032509
MAK16
MAK16 homolog (S. cerevisiae)
chr17_-_39093671 8.928 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr5_-_137878901 8.883 ETF1
eukaryotic translation termination factor 1
chr7_+_99006650 8.883 BUD31
BUD31 homolog (S. cerevisiae)
chr1_+_183441445 8.856 NM_001174061
NM_173156
NM_201568
NM_201569
SMG7



smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)



chr4_+_30722191 8.764 PCDH7
protocadherin 7
chr4_+_30722445 8.756 PCDH7
protocadherin 7
chr15_-_74495528 8.730 NM_001142618
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr9_+_35732629 8.729 CREB3
cAMP responsive element binding protein 3
chr7_+_108210188 8.697 NM_012328
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr14_+_96829849 8.691 C14orf129
chromosome 14 open reading frame 129
chr19_-_59030920 8.681 NM_032792
ZBTB45
zinc finger and BTB domain containing 45
chr5_-_140070953 8.658 NM_002109
HARS
histidyl-tRNA synthetase
chr2_+_201676260 8.616 NM_001207067
NM_014670
BZW1

basic leucine zipper and W2 domains 1

chr19_+_38865184 8.586 NM_002812
PSMD8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr19_-_58951588 8.574 NM_003433
ZNF132
zinc finger protein 132
chr12_+_133067156 8.562 NM_001142641
FBRSL1
fibrosin-like 1
chr19_-_46295647 8.558 DMWD
dystrophia myotonica, WD repeat containing
chr14_-_24711767 8.557 NM_001099274
NM_012461
TINF2

TERF1 (TRF1)-interacting nuclear factor 2

chr11_+_65408191 8.546 SIPA1
signal-induced proliferation-associated 1
chr9_-_132404277 8.541 NM_001202403
NM_017873
NM_177999
ASB6


ankyrin repeat and SOCS box containing 6



Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.51 2.11e-54 GO:0044260 cellular macromolecule metabolic process
1.37 2.98e-47 GO:0044237 cellular metabolic process
1.80 2.70e-44 GO:0010467 gene expression
1.81 4.20e-42 GO:0016070 RNA metabolic process
1.60 7.69e-41 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.68 7.57e-40 GO:0090304 nucleic acid metabolic process
1.40 1.40e-39 GO:0043170 macromolecule metabolic process
2.34 3.76e-37 GO:0006396 RNA processing
1.28 5.08e-34 GO:0008152 metabolic process
1.30 2.59e-32 GO:0044238 primary metabolic process
1.48 7.87e-31 GO:0034641 cellular nitrogen compound metabolic process
3.16 5.79e-29 GO:0071843 cellular component biogenesis at cellular level
1.45 1.34e-28 GO:0006807 nitrogen compound metabolic process
3.21 1.73e-28 GO:0022613 ribonucleoprotein complex biogenesis
2.29 1.98e-28 GO:0016071 mRNA metabolic process
1.49 2.70e-23 GO:0044267 cellular protein metabolic process
3.42 3.44e-21 GO:0042254 ribosome biogenesis
2.58 1.03e-20 GO:0034660 ncRNA metabolic process
1.58 1.33e-20 GO:0034645 cellular macromolecule biosynthetic process
2.29 3.08e-20 GO:0006397 mRNA processing
1.57 8.46e-20 GO:0009059 macromolecule biosynthetic process
2.42 7.89e-19 GO:0008380 RNA splicing
2.69 3.34e-16 GO:0034470 ncRNA processing
3.51 5.42e-16 GO:0006364 rRNA processing
1.42 5.61e-16 GO:0044249 cellular biosynthetic process
3.38 2.60e-15 GO:0016072 rRNA metabolic process
1.77 3.71e-15 GO:0046907 intracellular transport
2.56 7.89e-15 GO:0000375 RNA splicing, via transesterification reactions
2.57 1.65e-14 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.57 1.65e-14 GO:0000398 nuclear mRNA splicing, via spliceosome
1.11 2.15e-14 GO:0009987 cellular process
3.54 1.74e-13 GO:0006353 transcription termination, DNA-dependent
1.37 2.16e-13 GO:0009058 biosynthetic process
1.36 2.84e-13 GO:0071841 cellular component organization or biogenesis at cellular level
2.17 8.27e-13 GO:0006412 translation
1.30 2.24e-12 GO:0071840 cellular component organization or biogenesis
1.98 4.14e-12 GO:0016032 viral reproduction
1.32 5.12e-12 GO:0019538 protein metabolic process
1.62 1.30e-10 GO:0015031 protein transport
1.61 2.60e-10 GO:0045184 establishment of protein localization
1.51 3.49e-10 GO:0044085 cellular component biogenesis
2.60 5.45e-10 GO:0007005 mitochondrion organization
1.60 1.39e-09 GO:0033554 cellular response to stress
2.98 2.00e-09 GO:0071826 ribonucleoprotein complex subunit organization
2.95 1.93e-08 GO:0022618 ribonucleoprotein complex assembly
1.73 2.94e-08 GO:0006974 response to DNA damage stimulus
1.49 3.47e-08 GO:0008104 protein localization
1.44 4.03e-08 GO:0033036 macromolecule localization
1.51 7.19e-08 GO:0032774 RNA biosynthetic process
1.43 1.21e-07 GO:0051641 cellular localization
2.91 1.83e-07 GO:0006354 transcription elongation, DNA-dependent
1.46 2.22e-07 GO:0051649 establishment of localization in cell
1.68 4.30e-07 GO:0044265 cellular macromolecule catabolic process
1.33 4.80e-07 GO:0043412 macromolecule modification
1.94 5.36e-07 GO:0032446 protein modification by small protein conjugation
1.85 5.67e-07 GO:0070647 protein modification by small protein conjugation or removal
1.23 1.72e-06 GO:0016043 cellular component organization
1.27 2.20e-06 GO:0071842 cellular component organization at cellular level
2.29 4.11e-06 GO:0048193 Golgi vesicle transport
2.59 5.23e-06 GO:0006352 transcription initiation, DNA-dependent
1.92 5.59e-06 GO:0016567 protein ubiquitination
1.48 5.60e-06 GO:0006351 transcription, DNA-dependent
1.41 9.46e-06 GO:0044248 cellular catabolic process
1.57 1.09e-05 GO:0009057 macromolecule catabolic process
1.72 1.19e-05 GO:0006886 intracellular protein transport
1.33 1.87e-05 GO:0006996 organelle organization
3.33 2.04e-05 GO:0006369 termination of RNA polymerase II transcription
1.77 2.20e-05 GO:0051603 proteolysis involved in cellular protein catabolic process
1.35 2.21e-05 GO:0009056 catabolic process
1.82 2.29e-05 GO:0006366 transcription from RNA polymerase II promoter
2.65 2.64e-05 GO:0006839 mitochondrial transport
1.30 3.07e-05 GO:0006464 protein modification process
1.77 3.52e-05 GO:0043632 modification-dependent macromolecule catabolic process
2.51 6.21e-05 GO:0018196 peptidyl-asparagine modification
2.51 6.21e-05 GO:0018279 protein N-linked glycosylation via asparagine
1.74 6.31e-05 GO:0044257 cellular protein catabolic process
1.76 8.51e-05 GO:0006511 ubiquitin-dependent protein catabolic process
1.95 1.09e-04 GO:0006457 protein folding
2.69 1.12e-04 GO:0072594 establishment of protein localization to organelle
1.74 1.14e-04 GO:0019941 modification-dependent protein catabolic process
1.69 1.32e-04 GO:0030163 protein catabolic process
2.41 1.52e-04 GO:0006487 protein N-linked glycosylation
3.57 1.64e-04 GO:0006626 protein targeting to mitochondrion
1.57 2.22e-04 GO:0070727 cellular macromolecule localization
1.87 2.86e-04 GO:0009261 ribonucleotide catabolic process
4.29 3.20e-04 GO:0006362 transcription elongation from RNA polymerase I promoter
2.86 3.25e-04 GO:0006521 regulation of cellular amino acid metabolic process
3.46 3.39e-04 GO:0072655 establishment of protein localization in mitochondrion
2.72 4.08e-04 GO:0006368 transcription elongation from RNA polymerase II promoter
1.86 4.45e-04 GO:0009154 purine ribonucleotide catabolic process
1.87 4.62e-04 GO:0009203 ribonucleoside triphosphate catabolic process
1.87 4.62e-04 GO:0009207 purine ribonucleoside triphosphate catabolic process
2.20 4.71e-04 GO:0006399 tRNA metabolic process
1.55 4.98e-04 GO:0034613 cellular protein localization
1.86 5.65e-04 GO:0009146 purine nucleoside triphosphate catabolic process
2.46 5.83e-04 GO:0031575 mitotic cell cycle G1/S transition checkpoint
2.46 5.83e-04 GO:0071779 G1/S transition checkpoint
1.96 5.96e-04 GO:0043687 post-translational protein modification
2.00 6.09e-04 GO:0010498 proteasomal protein catabolic process
2.00 6.09e-04 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
3.35 6.70e-04 GO:0070585 protein localization in mitochondrion
2.57 6.90e-04 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
4.08 8.96e-04 GO:0006363 termination of RNA polymerase I transcription
1.80 1.02e-03 GO:0006195 purine nucleotide catabolic process
1.83 1.02e-03 GO:0009143 nucleoside triphosphate catabolic process
2.85 1.04e-03 GO:0050434 positive regulation of viral transcription
3.80 1.37e-03 GO:0006360 transcription from RNA polymerase I promoter
3.80 1.37e-03 GO:0006361 transcription initiation from RNA polymerase I promoter
1.73 1.40e-03 GO:0010608 posttranscriptional regulation of gene expression
1.77 1.40e-03 GO:0072523 purine-containing compound catabolic process
2.10 1.49e-03 GO:0006403 RNA localization
2.39 2.06e-03 GO:0051443 positive regulation of ubiquitin-protein ligase activity
2.55 2.15e-03 GO:0071158 positive regulation of cell cycle arrest
2.34 2.35e-03 GO:0051168 nuclear export
2.34 2.35e-03 GO:0051351 positive regulation of ligase activity
2.34 2.35e-03 GO:2000045 regulation of G1/S transition of mitotic cell cycle
2.58 2.56e-03 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
2.58 2.56e-03 GO:0072395 signal transduction involved in cell cycle checkpoint
2.58 2.56e-03 GO:0072401 signal transduction involved in DNA integrity checkpoint
2.58 2.56e-03 GO:0072404 signal transduction involved in G1/S transition checkpoint
2.58 2.56e-03 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
2.58 2.56e-03 GO:0072422 signal transduction involved in DNA damage checkpoint
2.58 2.56e-03 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
2.58 2.56e-03 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
1.18 2.72e-03 GO:0060255 regulation of macromolecule metabolic process
1.39 3.69e-03 GO:0043933 macromolecular complex subunit organization
3.30 4.04e-03 GO:0000387 spliceosomal snRNP assembly
3.30 4.04e-03 GO:0009452 RNA capping
2.07 4.04e-03 GO:0050657 nucleic acid transport
2.07 4.04e-03 GO:0050658 RNA transport
2.07 4.04e-03 GO:0051236 establishment of RNA localization
1.72 4.45e-03 GO:0009166 nucleotide catabolic process
2.41 5.39e-03 GO:0051352 negative regulation of ligase activity
2.41 5.39e-03 GO:0051444 negative regulation of ubiquitin-protein ligase activity
1.53 6.28e-03 GO:0016044 cellular membrane organization
2.10 6.34e-03 GO:0031398 positive regulation of protein ubiquitination
2.10 6.34e-03 GO:0051028 mRNA transport
2.43 6.59e-03 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.88 7.19e-03 GO:0006486 protein glycosylation
1.88 7.19e-03 GO:0043413 macromolecule glycosylation
2.38 7.62e-03 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.53 8.02e-03 GO:0061024 membrane organization
2.46 8.03e-03 GO:0033238 regulation of cellular amine metabolic process
1.87 8.84e-03 GO:0070085 glycosylation
1.49 1.28e-02 GO:0034621 cellular macromolecular complex subunit organization
3.21 1.35e-02 GO:0006370 mRNA capping
2.54 1.41e-02 GO:0046782 regulation of viral transcription
1.51 1.72e-02 GO:0044262 cellular carbohydrate metabolic process
1.65 1.88e-02 GO:0034655 nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
1.65 1.88e-02 GO:0034656 nucleobase, nucleoside and nucleotide catabolic process
2.84 1.96e-02 GO:0006888 ER to Golgi vesicle-mediated transport
2.40 2.00e-02 GO:0031124 mRNA 3'-end processing
1.59 2.05e-02 GO:0009259 ribonucleotide metabolic process
1.91 2.06e-02 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
1.76 2.08e-02 GO:0009101 glycoprotein biosynthetic process
2.14 2.62e-02 GO:0051438 regulation of ubiquitin-protein ligase activity
2.11 2.71e-02 GO:0051340 regulation of ligase activity
1.96 2.80e-02 GO:0045333 cellular respiration
2.37 2.82e-02 GO:0006367 transcription initiation from RNA polymerase II promoter
1.89 3.16e-02 GO:0000082 G1/S transition of mitotic cell cycle
2.83 3.53e-02 GO:0006612 protein targeting to membrane
1.39 3.58e-02 GO:0065003 macromolecular complex assembly
1.56 3.85e-02 GO:0018193 peptidyl-amino acid modification
2.18 4.00e-02 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
1.42 4.02e-02 GO:0071822 protein complex subunit organization
1.56 4.18e-02 GO:0006281 DNA repair
3.26 4.33e-02 GO:0008334 histone mRNA metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.24 3.69e-86 GO:0005622 intracellular
1.24 6.60e-85 GO:0044424 intracellular part
1.31 5.31e-71 GO:0043227 membrane-bounded organelle
1.31 1.63e-70 GO:0043231 intracellular membrane-bounded organelle
1.27 2.26e-67 GO:0043229 intracellular organelle
1.27 3.57e-67 GO:0043226 organelle
1.37 4.25e-43 GO:0005634 nucleus
1.36 8.13e-41 GO:0044446 intracellular organelle part
1.66 1.27e-40 GO:0070013 intracellular organelle lumen
1.65 2.01e-40 GO:0031974 membrane-enclosed lumen
1.67 1.18e-39 GO:0044428 nuclear part
1.35 1.52e-39 GO:0044422 organelle part
1.64 1.27e-38 GO:0043233 organelle lumen
1.71 4.04e-36 GO:0031981 nuclear lumen
2.42 6.18e-35 GO:0030529 ribonucleoprotein complex
1.23 5.16e-33 GO:0005737 cytoplasm
1.28 9.74e-27 GO:0044444 cytoplasmic part
2.19 1.63e-24 GO:0005730 nucleolus
1.37 4.20e-22 GO:0032991 macromolecular complex
1.65 7.30e-21 GO:0005654 nucleoplasm
1.76 7.92e-15 GO:0044451 nucleoplasm part
1.53 4.28e-14 GO:0005739 mitochondrion
2.37 1.08e-13 GO:0016604 nuclear body
1.40 2.36e-13 GO:0005829 cytosol
2.74 7.45e-13 GO:0005681 spliceosomal complex
1.32 4.46e-12 GO:0043228 non-membrane-bounded organelle
1.32 4.46e-12 GO:0043232 intracellular non-membrane-bounded organelle
1.05 5.28e-11 GO:0044464 cell part
1.05 5.67e-11 GO:0005623 cell
1.66 3.34e-10 GO:0044429 mitochondrial part
3.84 5.75e-10 GO:0015030 Cajal body
1.33 8.51e-09 GO:0031090 organelle membrane
1.55 2.02e-07 GO:0031967 organelle envelope
1.24 5.90e-07 GO:0043234 protein complex
2.08 8.38e-07 GO:0005840 ribosome
1.52 8.98e-07 GO:0031975 envelope
4.19 1.40e-06 GO:0044452 nucleolar part
1.66 2.63e-06 GO:0031966 mitochondrial membrane
1.63 5.94e-06 GO:0005740 mitochondrial envelope
2.23 1.74e-05 GO:0016607 nuclear speck
5.29 1.24e-04 GO:0005732 small nucleolar ribonucleoprotein complex
2.43 1.48e-04 GO:0071013 catalytic step 2 spliceosome
3.38 2.09e-04 GO:0030532 small nuclear ribonucleoprotein complex
3.80 2.41e-04 GO:0005689 U12-type spliceosomal complex
2.59 2.55e-04 GO:0000502 proteasome complex
1.59 1.62e-03 GO:0019866 organelle inner membrane
1.62 1.69e-03 GO:0005743 mitochondrial inner membrane
3.00 2.28e-03 GO:0009295 nucleoid
1.99 3.11e-03 GO:0044455 mitochondrial membrane part
2.28 3.60e-03 GO:0016591 DNA-directed RNA polymerase II, holoenzyme
1.84 6.10e-03 GO:0044445 cytosolic part
2.39 6.15e-03 GO:0015934 large ribosomal subunit
2.91 6.90e-03 GO:0042645 mitochondrial nucleoid
1.61 1.55e-02 GO:0005759 mitochondrial matrix
1.80 2.97e-02 GO:0000151 ubiquitin ligase complex
1.27 3.93e-02 GO:0005783 endoplasmic reticulum
1.84 4.55e-02 GO:0031968 organelle outer membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.96 4.15e-27 GO:0003723 RNA binding
1.23 1.84e-25 GO:0005515 protein binding
1.11 1.54e-19 GO:0005488 binding
1.35 1.74e-18 GO:0003676 nucleic acid binding
1.29 2.85e-07 GO:0000166 nucleotide binding
1.17 5.15e-07 GO:0003824 catalytic activity
2.12 2.51e-06 GO:0008168 methyltransferase activity
2.06 9.22e-06 GO:0016741 transferase activity, transferring one-carbon groups
2.59 9.36e-06 GO:0008135 translation factor activity, nucleic acid binding
2.06 7.97e-05 GO:0003735 structural constituent of ribosome
1.25 7.62e-04 GO:0017076 purine nucleotide binding
1.25 9.17e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.24 1.46e-03 GO:0032553 ribonucleotide binding
1.24 1.46e-03 GO:0032555 purine ribonucleotide binding
1.25 2.05e-03 GO:0016740 transferase activity
2.61 5.52e-03 GO:0016251 general RNA polymerase II transcription factor activity
3.24 6.65e-03 GO:0008173 RNA methyltransferase activity
1.87 1.36e-02 GO:0004386 helicase activity
2.55 1.46e-02 GO:0003743 translation initiation factor activity
1.96 1.60e-02 GO:0051082 unfolded protein binding
2.04 2.06e-02 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
1.44 2.95e-02 GO:0016874 ligase activity
1.23 3.10e-02 GO:0030554 adenyl nucleotide binding
1.23 4.55e-02 GO:0005524 ATP binding
1.32 4.65e-02 GO:0016462 pyrophosphatase activity
1.23 4.76e-02 GO:0032559 adenyl ribonucleotide binding